- Medina County was founded on February 12, 1848, and was named after the Medina River.
- “Madina” is pronounced as MA-DEAN-ah.
- The county was formed from Bexar County.
- The county has no slogan yet.
- The county covers an area of 1,335 sq. mi. (3,460 km2).
- The City of Hondo serves as its county seat since 1892. Originally, it was the City of Castroville. Hondo is located in the center of the county.
- Medina Dam is the fourth largest dam in the nation and was completed in 1913. This dam helped from Medina Lake.
- An alternative rock band from Chicago shares a name with Madina Lake.
- Madina Lake is not to be confused with Lake Madina in Ohio.
- The ghost town of Vandenburg was abandoned for New Fountain in 1846; which late became a ghost town as well.
- Atascosa County (Southeast)
- Bandera County (North)
- Bexar County (East)
- Frio County (South)
- Uvalde County (West)
- New Fountain
- Old D’Hanis
- Lost Maples State Natural Area
- Love Creek Orchards
- Medina Lake